The Reds need a point at least to seal a last-16 spot, while a win guarantees top spot.
With Wijnaldum and Lovren back, Jurgen Klopp still has a strong squad to pick from, though there will be decisions to take at centre-back and in central midfield, in particular.
Curtis Jones is included in the squad, however, and the young midfielder will be on the bench for the second game in succession, with third-choice goalkeeper Caoimhin Kelleher the travelling player who will not be in the matchday squad.
The smart money might be on a strongest-possible lineup after recent rotations, meaning Mohamed Salah, Roberto Firmino and Sadio Mane all start, with Wijnaldum coming back into midfield alongside either Alex Oxlade-Chamberlain or Naby Keita, with Jordan Henderson deepest.
Klopp’s men simply need to get the job done here, to continue the defence of their Champions League crown and move into the knockout stages where we have been so strong over the last two years.
Liverpool squad travelling to Salzburg
Defenders: Van Dijk, Gomez, Robertson, Alexander-Arnold, Lovren
Midfielders: Henderson, Wijnaldum, Milner, Oxlade-Chamberlain, Keita, Jones
Forwards: Firmino, Mane, Salah, Origi, Shaqiri