Lincoln booked their place in the third round of the competition by dismantling Bradford to the tune of 5-0 on Tuesday night, setting up a meeting with the Premier League champions next week.
It will be the first time Appleton has managed a team against Liverpool and, of course, stood in the opposing dugout to Klopp.
The Imps will play hosts for the tie at Sincil Bank and if selected for TV will receive a much-needed financial boost, as the League One side continue to be hit by matches played behind-closed-doors.
And while the Reds are set to field a much-changed side from the one to feature against Chelsea on Sunday, claims of facing a ‘weakened’ lineup have been dismissed by the Lincoln manager after witnessing Liverpool’s fringe and youth players in cup action last season.
“The reality is they’re Premier League champions. If you look at the teams they put out in the FA Cup last season – and got a bit of stick for – they were still decent sides,” Appleton said, via Lincolnshire Live.
“It’s going to be a great occasion for everybody at the club. They’re full of talent. Even their second team is a side you wouldn’t mind looking after every week. We’ll give it our best shot.”
It is a far cry from the reaction served up by Shrewsbury in the FA Cup, who labelled Klopp and the club “disrespectful” for holding back their first-team players during the replay earlier this year.
It will be the second successive season the Reds have faced League One opposition in the third round following on from their 2-0 win over MK Dons last season, and there’s no doubt they will be put through their paces against a side out to topple the best team in the country.
Appleton, a boyhood Man United fan once on their books, has respect in abundance for his opposing manager and is relishing the chance to test his side against the very best.
“I’m saying this as Manchester United fan, the work he’s done at that football club is outstanding,” the Lincoln boss added.
“People talk about Pep and Klopp and Mourinho. In my eyes, we’ll be coming up against the best manager in the world.
“It’s going to be a test, but one I’m looking forward to. It’s an opportunity for the players to test themselves against the best in the country.”