The Reds have had a nightmare few days stretching back to a dramatic Merseyside derby, with injury and VAR controversy dominating the headlines in the lead up to this game.
The biggest news, of course, is the long-term absence of Virgil van Dijk after a nasty challenge from Jordan Pickford resulted in a grade three ACL tear, while Thiago too felt the brunt from a late Richarlison tackle and as a result was not part of the travelling party.
Adrian will continue to deputise between the sticks while Fabinho drops into the centre of defence alongside Joe Gomez, with Trent Alexander-Arnold and Andy Robertson continuing their full-back duties.
With European competitions continuing the rule to name an extended squad of up to 12 substitutes, of which five can be made, Klopp has a number of options at his disposal.
Ajax: Onana; Mazraoui, Schuurs, Blind, Tagliafico; Klaasen, Gravenberch, Martinez; Neres, Kudus, Tadic
Substitutes: Stekelenburg, Kotarski, Alvarez, Klaiber, Huntelaar, Promes, Ekkelenkamp, Labyad, Traore
Substitutes: Kelleher, Jaros, R.Williams, N.Williams, Henderson, Cain, Jota, Minamino, Shaqiri, Origi