The Reds are looking to follow up their 3-1 win over the Gunners last time out, and the 7-2 thrashing of Lincoln in the third round, when they take to Anfield tonight.
Tonight will be only Wilson’s second game for the first team, coming almost four years after his debut in the 1-0 FA Cup third-round replay win over Plymouth Argyle in January 2017.
Among the substitutes are Fabinho, Gini Wijnaldum and Andy Robertson, with the depth of Klopp’s squad despite a number of injuries giving Liverpool a strong chance of progressing to the quarter-finals.
The Reds played Arsenal in the fourth round this time last year, with a wild 5-5 draw played out at Anfield before Jones scored the decisive spot-kick to send his side through.
Mikel Arteta has made eight changes to his XI from Monday night, with Bernd Leno, Rob Holding and Granit Xhaka the only players to start both as the likes of Dani Ceballos, Nicolas Pepe and Eddie Nketiah come in.
Liverpool: Adrian; N.Williams, R.Williams, Van Dijk, Milner; Grujic, Jones; Wilson, Minamino, Jota; Salah
Substitutes: Kelleher, Gomez, Robertson, Fabinho, Wijnaldum, Elliott, Origi
Arsenal: Leno; Cedric, Holding, Gabriel, Kolasinac; Xhaka, Willock, Ceballos; Pepe, Saka, Nketiah
Substitutes: Runarsson, Luiz, Tierney, Elneny, Maitland-Niles, Nelson