The Reds have enjoyed the luxury of a full week of preparations for this top-of-the-table clash, having last played in the 4-1 victory over a young Aston Villa in the FA Cup.
Mohamed Salah, Sadio Mane and Roberto Firmino line up in attack, with a miserly record of just three goals and an assist in 23 combined appearances against United setting the challenge out for Liverpool’s front three.
The system could be either a 4-3-3 or 4-2-3-1, with Shaqiri an option either in midfield or, particularly if Salah switches to the centre-forward role, on the right.
Substitutes: Kelleher, R.Williams, Phillips, N.Williams, Milner, Oxlade-Chamberlain, Jones, Minamino, Origi
Man United: De Gea; Wan-Bissaka, Lindelof, Maguire, Shaw; Pogba, Fred, McTominay; Fernandes, Rashford, Martial
Substitutes: Henderson, Bailly, Telles, Tuanzebe, Matic, Van de Beek, Mata, Greenwood, Cavani