The game is to remain at the scheduled date of February 16 with an 8pm (GMT) kickoff but has been moved from Germany to Hungary due to COVID-19 restrictions.
The location of the game had been thrown into doubt after the German government placed a ban on all arrivals from countries where new coronavirus variants existed until February 17.
An application had been submitted to see Liverpool be exempt from such restrictions but was denied, and as such Leipzig were left to find an alternative with Red Bull Arena off the cards.
As it stands, the second leg remains scheduled for March 10 at Anfield.
“The date of the match and kick-off time (21:00CET) will remain the same.
“UEFA would like to thank RB Leipzig and Liverpool FC for their close cooperation and assistance in finding a solution to the issue at hand, as well as the Hungarian Football Federation for their support and agreeing to host the match in question.”