The Reds picked up one of their all-time great victories last weekend, thumping United 5-0 at Old Trafford to heap misery on their rivals.
Here are 10 things to know ahead of the game.
1. Brighton make strong start
Last season, there was a feeling that Brighton played better than their results merited, often producing good football but proving to be sloppy at both ends of the pitch.
The Seagulls have ensured that hasn’t been the case in 2021/22 to date, though, sitting fifth in the table and only suffering defeat twice.
Graham Potter is an impressive young manager who has got his side playing an attractive style and he could be eyed up by bigger clubs in the near future.
Brighton‘s form has dipped a little in recent weeks, however, with no wins in their last four league games – Potter will be desperate to ensure this doesn’t turn into a genuine slump.
2. Who’s missing for the Seagulls?
Brighton have an almost clean bill of health ahead of the trip to Liverpool, although giant defender Dan Burn will miss out.
Adam Webster is expected to replace Burn, with a 3-5-2 likely to be adopted, as was the case in last weekend’s 4-1 defeat at home to Man City.
Possible Brighton XI: Sanchez; Veltman, Dunk, Webster; March, Gross, Bissouma, Lallana, Cucurella; Trossard, Maupay.
3. Liverpool injury news
Liverpool’s midfield injury woes have received a boost, with Naby Keita available for Saturday’s game.
The Guinean was exceptional against United, scoring and assisting, and he returned to training on Thursday after being stretchered off at Old Trafford.
Unfortunately, Fabinho is still out with a knock to the knee that Klopp said is “complicated enough to keep him out now again” while Thiago isn’t yet ready to return to the team, even though he is back in training.
4. How the Reds could line-up
Klopp will be wary of overplaying certain individuals so he could rotate this weekend, especially with Atletico Madrid heading to Anfield next Wednesday.
There is also the option of resting Virgil van Dijk, as Liverpool continue to manage him sensibly.
If Klopp is feeling particularly bold at home to weaker opposition, he could play Diogo Jota as well, going with a 4-2-3-1 formation.
Predicted Liverpool XI: Alisson; Alexander-Arnold, Matip, Van Dijk, Robertson; Henderson, Keita, Jones; Salah, Mane, Firmino.
5. Almost immaculate record against Brighton
That included a 5-1 triumph at the Amex Stadium back in December 2017.
It was the Seagulls who enjoyed the better of the fixture in 2020/21, however, with Pascal Gross’ stoppage-time penalty earning them a 1-1 home draw last November after Diogo Jota opened the scoring.
Potter’s side then inflicted a 1-0 defeat on Liverpool at Anfield back in February – Steven Alzate scored the goal – during the Reds’ unfathomable six-game losing streak at home.
6. Klopp praises Lallana
Klopp and Lallana used to be next-door neighbours with a strong relationship and it is clear that the former thinks highly of the latter.
Speaking in his pre-match press conference, Klopp hailed his former player and bemoaned the injury problems that held him back:
“I miss Adam still to be honest. He set the standard for the press from the first day to the last day. That is what I loved about him.”
“A football player with his technical skills and that working mentality is really rare.
“If he was injured a little bit less he would be on another level. He is one of the best players I’ve ever worked with.”
If Lallana plays on Saturday, he is sure to get a fantastic reception from the home crowd.
7. United win “not perfect”
Liverpool fans may still be revelling in the Reds’ masterclass, but Klopp isn’t resting on his laurels in the slightest.
He told reporters that he still expects more from his team going into the weekend action:
“You win 5-0 against United and it was perfect, but it was not. United have clear cut chances which we gave them and we shouldn’t rely on luck or Ali in these moments.
“We could have done better. That’s how we spoke at half-time 4-0 up. I told the boys, believe me, we have to play better otherwise we open up the game for them.
“I saw in the first half we gave too much away, that’s the things we have to improve and not just in that game but in general.”
Part of Klopp’s brilliance is never settling for anything other than perfect and it has helped Liverpool become the force that they are.
8. Did you know?
Aside from the incredible form of Salah, the return of Van Dijk has been the key reason for Liverpool getting back to their very best again.
Incredibly, the Dutchman is still yet to lose a single league game for Liverpool in 51 appearances at Anfield, despite his four-anniversary at the club fast approaching.
That’s 44 wins and seven draws in that time – astonishing stuff.
The Reds did of course lose six times at home last season, but Van Dijk was sidelined at that point with his cruciate ligament injury.
He is a true great of the game.
9. Mike Dean in charge
No Premier League referee loves being in the spotlight more than Mike Dean, which means it’s always slightly worrying when he is in charge.
That is the case on Saturday afternoon, with the Tranmere fan refereeing proceedings at Anfield.
He did afford Burnley a soft penalty at Anfield last season, however, on a night that saw the Reds’ almost four-year unbeaten home league record end.
10. Saturday 3pm blackout
Saturday’s game is a 3pm (BST) kickoff, which means it can’t be shown live in the UK.
TIA’s matchday live blog is running as always, though, making it the best place to keep up-to-date as all the action unfolds.
Joanna Durkan is in charge from 2.15pm, providing pre-match insight and regular updates during the game.