The Reds arrive at Deepdale buoyed by a remarkable 5-0 win at Man United, though few of the players from that triumph at Old Trafford are expected to be involved.
Just as with the 3-0 win over Norwich in the previous round, Klopp should turn to a mix of fringe figures and youth for his starting lineup against the Championship strugglers.
However, Liverpool will not take to tie lightly, with there being no chance of an academy side being fielded, for example.
So how could the Reds line up in Lancashire?
- Naby Keita and Fabinho out, but likely back vs. Brighton
- Caoimhin Kelleher also a doubt due to illness
- James Milner and Thiago longer-term absentees, but Spaniard improving
- Divock Origi and Takumi Minamino expected to return
- Kaide Gordon to miss out but youngsters likely to take part
Liverpool’s XI vs. Preston
- Adrian to start in goal if Kelleher is out
- Neco Williams and Kostas Tsimikas in at full-back
- Gomez the likely partner for a returning Joel Matip
- Morton to get first start with Jones and Alex Oxlade-Chamberlain
- Sadio Mane the key forward alongside Minamino and Origi
This would see Liverpool set up as below:
There is a possibility that further alterations are made to that lineup, however, particularly if Kelleher is deemed fit to start.
- If fit, Kelleher to resume duties as cup goalkeeper
- Nat Phillips a candidate at centre-back if Matip rested for Brighton
- Morton, Jones, Oxlade-Chamberlain midfield the most feasible
- Mateusz Musialowski and James Balagizi unlikely starters in attack
With Kelleher and Phillips to come in, Liverpool could take to the field like this:
Kelleher; Williams, Phillips, Gomez, Tsimikas; Morton, Oxlade-Chamberlain, Jones; Mane, Minamino, Origi
As mentioned, the likes of Musialowski and Balagizi may make the matchday squad after missing the under-23s’ 2-2 draw with Blackburn on Monday night, while Owen Beck and Conor Bradley could be involved having seen their minutes limited in that game.
But there is a low chance of Klopp taking too many risks despite Liverpool’s priorities being elsewhere – particularly as there are senior players in need of the game time.