The Reds head into the crucial Premier League clash off the back of an emphatic 5-1 over Porto in midweek, a result that stretched the unbeaten start to the season to nine games.
The result also ensured Liverpool have now scored three or more goals in their last six games but making it seven will prove tough going against a City side who have conceded just once in six league matches.
But the match offers a chance to set an early benchmark and Fortress Anfield will be right behind Liverpool as they look to remain at the top of the table.
Alisson will continue in goal, looking for his fifth clean sheet a day after his 29th birthday.
Substitutes: Kelleher, Gomez, Konate, Tsimikas, Williams, Keita, Oxlade-Chamberlain, Minamino, Firmino
Man City: Ederson; Walker, Dias, Laporte, Cancelo; Rodri, De Bruyne, Bernardo; Foden, Grealish, Jesus
Substitutes: Steffen, Carson, Stones, Ake, Sterling, Torres, Fernandinho, Mahrez, Palmer