The Reds drew 3-3 at home to Benfica to reach the Champions League quarter-finals on Wednesday, setting up a meeting with Villarreal in what will be their third semi-final this season.
Next up is another weekend showdown with City, having played out a second 2-2 draw of the season in the Premier League just six days ago.
One team could end this season with a quadruple, while the other could win a treble. One of those opportunities will end on Saturday afternoon.
Here are 10 key things to know ahead of the huge match.
1. City battle past Atletico
While Liverpool were able to get past Benfica in a relatively comfortable fashion, City had an energy-sapping night away to Atletico Madrid.
Pep Guardiola’s men battled their way to a goalless draw in Spain, as the La Liga champions kicked their opponents to shreds.
The physical toll that the game may have taken on City’s players shouldn’t be played down going into the showdown with Liverpool.
Klopp’s side are arguably favourites going into the game now.
2. Injury concerns for City
Both Kyle Walker and Kevin De Bruyne failed to finish the Atletico game, with the pair hobbling off with injury problems.
They have been ‘ruled out’ of Saturday’s match after failing to recover in time, but seeing will be believing with regards to that.
De Bruyne, in particular, has been in sensational form of late, scoring six goals in seven games, so his absence would be significant.
3. Predicted City XI
We’re not going to feel sorry for City because of a few injuries, though.
Guardiola will still be able to field a starting lineup stronger than almost anyone in Europe on Saturday, with a few tweaks expected after their midweek excursions.
Joao Cancelo will likely switch to right-back in the absence of Walker, meaning Nathan Ake will slot in at left-back for a rare outing.
Jack Grealish, Raheem Sterling and Gabriel Jesus could all come into the attack, having started on the bench in Madrid.
Possible City XI: Ederson; Cancelo, Stones, Laporte, Ake; Rodri, Gundogan, Bernardo; Jesus, Grealish, Sterling.
4. Who’s missing for Liverpool?
Liverpool are in their healthiest injury situation in years, with Klopp afforded the luxury of a fully available squad this weekend.
Diogo Jota picked up a knock against Benfica but should have recovered from it and there are no new issues to have arisen since then.
It’s slightly different to last season’s fitness woes, that’s for sure!
5. Possible Reds lineup
Klopp made seven changes on Wednesday and rested some of the key players, allowing them to recharge their batteries.
6. Klopp promises improved showing
Liverpool were far from their best at the Etihad, something Klopp admitted when speaking to the media on Thursday. The boss said he expects an improved performance this time around:
“I think City were really strong last week and we were not at our best. So I would like to see a game where we are at our best as well.
“It would be interesting, so let’s give it a try – that would be a surprise, all of a sudden we are good!
“The boys did a lot of good stuff in the game, but I really think in a couple of positions we are able to perform on a completely different level.
“I think we should give that a try.”
He just nails it every time, doesn’t he?
7. Liverpool’s recent FA Cup semi-final record
The Reds also won their three semi-final clashes before that, against Wycombe (2001), Villa (1996) and Portsmouth (1992), but fell foul to Crystal Palace back in 1990.
8. Did You Know?
This is only the sixth time that Liverpool and City have faced each other in the FA Cup, which may come as a surprise to some.
The first meeting came in the fifth round back in 1956, when the Citizens prevailed 2-1 at Anfield in a replay after an initial goalless draw at Maine Road.
City also won in a replay in the fourth round in 1973, before Liverpool thumped their opponents 4-0 away from home in the 1988 quarter-finals, thanks to goals from Ray Houghton, Craig Johnston, John Barnes and Peter Beardsley.
The Reds beat their opponents 4-2 in the fifth round in 2001, on their way to a cup treble, and also sealed a 1-0 win away from home in the third round in 2003, with a Danny Murphy penalty settling matters.
9. Oliver in charge
Many felt Michael Oliver should have been in charge of last weekend’s Premier League clash, with Manchester-born Anthony Taylor given the game instead.
Thankfully, arguably the country’s best referee will officiate Saturday’s game, while Darren England is on VAR duty.
10. Rare BBC offering
Saturday’s game is live on BBC One from 3pm, with kickoff at 3.30pm (BST).
This Is Anfield’s matchday live blog will also be available from 2.45pm, with a tense Henry Jackson talking you through the action.
Come on you Reds!