Sami Hyypia drops to the bench despite strong performances of late, making way for a central defensive partnership of Jamie Carragher and Martin Skrtel.
Fabio Aurelio gets the nod at left-back ahead of John Arne Riise whilest Steven Gerrard has shaken off a neck injury to captain the side, playing behind striker Fernando Torres.
Peter Crouch, Yossi Benayoun and Jermaine Pennant make up Liverpool’s attacking options on the bench.
Liverpool: Reina, Arbelona, Carragher, Skrtel, Aurelio, Kuyt, Mascherano, Alonso, Gerrard, Babel, Torres. Subs: Itandje, Hyypia, Riise, Pennant, Lucas, Crouch, Benayoun.
Kick-off at Anfield is 7.45pm.