The Slovakian international may be ruled out for two more weeks following his collision with Jamie Carragher in the first half of the Reds’ 2-1 defeat to Tottenham at the weekend.
So 18-year-old Spanish centre-back Daniel Ayala steps in to cover for Skrtel with Yossi Benayoun replacing Ryan Babel in midfield.
Liverpool: Reina, Insua, Johnson, Ayala, Carragher, Mascherano, Lucas, Benayoun, Kuyt, Gerrard, Torres. Subs: Cavalieri, Dossena, Voronin, Riera, Ngog, Babel, Kelly.
Kick-off at Anfield is 8pm.