Brad Jones continues to fill in in goal for the injured Pepe Reina, whilst Martin Skrtel replaces Jamie Carragher in central defence, partnering Daniel Agger.
Everton‘s victory earlier in the day against Manchester City means Liverpool have dropped to seventh, but victory over the Saints this afternoon could see Brendan Rodgers’ men lift to fifth, just four points off the Champions League places.
Southampton vs Liverpool gets underway at 3pm.
Liverpool: Jones, Johnson, Enrique, Agger, Skrtel, Allen, Gerrard, Downing, Coutinho, Sturridge, Suarez. Subs: Gulacsi, Wisdom, Henderson, Shelvey, Lucas, Suso, Ibe.