The Brazilian is one of nine changes as the German looks to shuffle his pack ahead of Saturday’s trip to Stamford Bridge to take on Chelsea in the Premier League, including full debuts for three of the Reds’ young stars.
Adam Bogdan takes up his position in goal, replacing first-choice goalkeeper Simon Mignolet.
Supporting lone striker Divock Origi, Firmino, Jordon Ibe and Joao Carlos Teixeira complete Klopp’s four-man attacking line.
Teixeira makes his first starting appearance for the Reds, three years after joining the club as a 19-year-old from Sporting CP.
After an impressive loan spell with Brighton and Hove Albion last season, the Portuguese will be hoping to secure a regular squad role under Klopp in 2015/16.
Much of the onus, however, is on Firmino, as Liverpool‘s most senior attacking charge.
Liverpool: Bogdan, Clyne, Toure, Lovren, Randall, Allen, Brannagan, Teixeira, Ibe, Firmino, Origi
Substitutes: Fulton, Skrtel, Moreno, Lucas, Lallana, Coutinho, Sinclair