It’s a relatively straight forward team selection for Klopp, with Flanagan not registered in Europe meaning Alberto Moreno and Clyne are the full backs – Clyne having been rested against Crystal Palace on Sunday.
Sturridge replaces Origi up front.
Sheyi Ojo is named among the subs after his hat-trick for the under-21s on Monday. Origi and Christian Benteke are other attacking subs.
There’s three changes for the visitors, as Varela, Schneiderlin and Fellaini come in for Darmian, Carrick and Herrera.
Kick off at Anfield tonight is 8.05pm (GMT).
Liverpool: Mignolet, Clyne, Lovren, Sakho, Moreno, Can, Henderson, Lallana, Firmino, Coutinho, Sturridge.
Subs: Ward, Toure, Benteke, Allen, Origi, Smith, Ojo.
Man United: De Gea, Varela, Smalling, Blind, Rojo, Schneiderlin, Fellaini, Memphis, Mata, Martial, Rashford.
Subs: Romero, Darmian, Riley, Carrick, Schweinsteiger, Weir, Herrera.