The Reds will take on one of the League Two sides at Anfield as they begin their FA Cup campaign, in what proves to be a busy start to 2017.
Due to broadcasting demands, their home tie has been scheduled for January 8, and will kick off at 1.30pm (GMT), live on BT Sport 2.
This presents a quandary for the German, who will be forced to contend a hugely demanding, congested schedule.
It is likely, therefore, that either Newport or Argyle, who play their second-round replay at Rodney Parade on December 21, will take on a heavily rotated Reds side.
Klopp utilised the likes of Kevin Stewart, Sheyi Ojo, Brad Smith, Jon Flanagan, Cameron Brannagan, Connor Randall, Joao Carlos Teixeira, Pedro Chirivella, Tiago Ilori, Jerome Sinclair, Joe Maguire and Ryan Kent in the FA Cup last season, and could do similar in 2017.
Teixeira, Sinclair and Smith all left the club in the summer, while Flanagan and Kent both went on loan and Ojo, Brannagan, Randall, Ilori, Maguire and Chirivella are yet to feature in 2016/17.
Ojo and Joe Gomez are both returning from long-term injury, and January 8 could present a sensible point for the young duo to make their first-team comeback.
However, Klopp will be desperate to ensure victory, with Liverpool not competing in Europe this season, and seeking success on three fronts.
LIVERPOOL FIXTURES, JANUARY 2017
- Newport/Plymouth (H) – FA Cup 3rd Round – January 8