And after a 2-2 draw at home to Bournemouth in midweek, Liverpool are in desperate need of a win against the Potters in order to preserve their top-four hopes.
Despite the absences of some of his star names, however, Klopp has still been able to name a strong starting lineup.
Simon Mignolet makes his 17th consecutive appearance in the Premier League, with the goalkeeper operating behind a back five of Nathaniel Clyne, Ragnar Klavan, Joel Matip, Dejan Lovren and James Milner.
Stoke City: Grant; Johnson, Shawcross, Martins Indi, Pieters; Shaqiri, Allen, Cameron, Arnautovic; Walters, Berahino
Substitutes: Given, Muniesa, Whelan, Adam, Diouf, Crouch, Ramadan
Liverpool: Mignolet; Clyne, Matip, Klavan, Lovren, Milner; Can, Wijnaldum, Alexander-Arnold; Woodburn, Origi
Substitutes: Karius, Lucas, Moreno, Grujic, Coutinho, Firmino, Sturridge