Speaking ahead of the weekend’s trip to the south coast, Klopp referenced the “special relationship” between the two clubs in recent seasons.
Six players have made the move to Merseyside in the past three-and-a-half years, with the most recent seeing the Saints procure a world-record transfer fee for a defender.
All eyes were on Klopp’s team-sheet in the buildup, and the German has named three of his ex-Saints in his matchday squad.
Liverpool have not won in any of their last three trips to St Mary’s, but take on a Southampton side mired in a relegation battle under Mauricio Pellegrino.
With a host of familiar faces in their midst, the Reds will be hoping a hostile atmosphere won’t prove too much of an issue as they bid for a return to winning ways after their 2-2 draw with Tottenham.
Southampton: McCarthy; Cedric, Stephens, Hoedt, Bertrand; Hojbjerg, Romeu, Lemina; Ward-Prowse, Tadic, Carrillo
Substitutes: Forster, Yoshida, Davis, Redmond, Boufal, Long, Gabbiadini
Liverpool: Karius; Alexander-Arnold, Matip, Van Dijk, Robertson; Can, Wijnaldum, Oxlade-Chamberlain; Salah, Mane, Firmino
Substitutes: Mignolet, Lovren, Moreno, Milner, Lallana, Ings, Solanke