A two-week interval could serve as a speed-bump for Klopp’s side, but the hope will be that, despite a clutch of fitness issues, a welcome rest for some of his key men will provide a boost.
Klopp effectively named his strongest side against the Hornets at Anfield, and only two of those drop out for the trip to Selhurst Park.
Loris Karius keeps his place in goal, after a short break to Miami having been left out of the Germany squad, with proving his worth to Joachim Low now an added incentive.
Liverpool have won each of their last three clashes with Palace on the road, while they recorded a 1-0 victory over the Eagles at Anfield back in August.
Mane got the only goal that day, and with just seven games left to play Klopp would no doubt take another marginal win against Roy Hodgson’s relegation candidates.
Crystal Palace: Hennessey; Wan-Bissaka, Sakho, Kelly, Van Aanholt; McArthur, Milivojevic, Cabaye; Townsend, Zaha, Benteke
Substitutes: Cavalieri, Delaney, Souare, Fosu-Mensah, Riedewald, Loftus-Cheek, Lee
Liverpool: Karius; Alexander-Arnold, Matip, Van Dijk, Robertson; Henderson, Milner, Wijnaldum; Salah, Mane, Firmino
Substitutes: Mignolet, Lovren, Clyne, Moreno, Oxlade-Chamberlain, Lallana, Ings