Right-back Kyle Walker, centre-half Nicolas Otamendi and midfielders David Silva and Kevin De Bruyne are all honoured, along with forward Sergio Aguero.
Denmark midfielder Christian Eriksen is also included, along with his Spurs team-mate Harry Kane, the England striker among three forwards in the side completed by Liverpool frontman Mohamed Salah, who has bagged 30 league goals so far this season.
City duo De Bruyne and Silva are shortlisted for the PFA’s Player of the Year award, along with club-mate Leroy Sane after all three helped Pep Guardiola’s side win the Premier League.
Kane, Salah and De Gea are also nominated, with the winner set to be announced at the PFA’s annual awards ceremony in London on Sunday, April 22.
Goalkeeper John Ruddy, defender Willy Boly and midfielder Ruben Neves, who scored a memorable goal in the recent win over Derby, all make the XI.
The battle to join them in the top flight next season looks set to go down to the wire.
Fulham head into the weekend’s matches in third place, just a point behind Cardiff, on the back of an impressive 21-match unbeaten Championship run.
The Cottagers see defender Ryan Fredericks and wing-back Ryan Sessegnon, who has scored 14 goals so far, named in the PFA Championship Team of the Year, along with midfielder Tom Cairney.
Cardiff centre-half Sol Bamba, Norwich midfielder James Maddison, Bristol City forward Bobby Reid, Sheffield United striker Leon Clarke and Derby frontman Matej Vydra are all acknowledged for their impressive campaigns.
Exciting Fulham prospect Sessegnon, 17, is also included on the shortlist for the PFA Young Player of the Year award.