The Reds arrive on the south coast just three days after a gruelling UEFA Super Cup victory over Chelsea, in which six outfielders played over 120 minutes.
That night in Istanbul saw Adrian prove the hero in a penalty shootout win, but the Spaniard suffered a troubling ankle injury due to the involvement of a pitch invader during the celebrations.
But Klopp’s second-choice ‘keeper has recovered in time to start, relieving a problem which could have seen Andy Lonergan make a very unexpected debut.
“The two midfielders with the highest work-rate on Wednesday night [come out of the team],” the manager explained of his changed.
“We have options so let’s do it.”
Southampton: Gunn; Yoshida, Vestergaard, Bednarek; Valery, Romeu, Hojbjerg, Bertrand; Redmond, Ward-Prowse, Adams
Substitutes: Forster, Cedric, Danso, Obafemi, Armstrong, Djenepo, Ings
Liverpool: Adrian; Alexander-Arnold, Matip, Van Dijk, Robertson; Wijnaldum, Milner, Oxlade-Chamberlain; Salah, Mane, Firmino
Substitutes: Lonergan, Gomez, Fabinho, Henderson, Lallana, Shaqiri, Origi