The Reds are back after the September international break with first taking on 14th in the Premier League.
With the majority of his senior squad departing on duty with their national teams over the past fortnight, and Liverpool playing seven games over the next 21 weeks, Klopp has rotated his side.
Oxlade-Chamberlain makes his 50th appearance for the Reds, and his first start at Anfield since his ACL injury in April 2018.
Though Newcastle are certainly not the most convincing of outfits, having won just once in four games so far in the league under Steve Bruce, Klopp is expecting a competitive clash.
“I think [they had] 24 or 25 percent possession at Tottenham, but always really, really good, scored a wonderful goal and defended with a big heart and good organisation,” he told reporters on Friday.
“That’s it. That’s what we had to prepare for and that’s what we did.
“So that will not be easy, that’s what people expect probably with all the difficulties they had in the summer.
“I’m really impressed by the solutions they found and the things they did so far.”
Substitutes: Kelleher, Gomez, Milner, Henderson, Lallana, Shaqiri, Firmino
Newcastle: Dubravka; Schar, Lascelles, Dummett; Krafth, Hayden, Shelvey, Willems; Almiron, Atsu, Joelinton
Substitutes: Darlow, Fernandez, Clark, Manquillo, Ki, M.Longstaff, Muto