Klopp gave a host of youngsters their first taste of competitive senior action in the 2-0 win over MK Dons in the third round, and has maintained this approach at Anfield.
Despite the Gunners representing a bigger test, the manager is keeping faith with his blend of future hopefuls and first-team staples short of game time.
Between the sticks is Caoimhin Kelleher, who makes his Anfield bow, having kept a clean sheet on his debut for the club last time out in the cup.
Koumetio, who joined the club from US Orleans earlier this year, will become the club’s fourth-youngest debutant if he comes off the bench.
Mesut Ozil starts for Arsenal, with Unai Emery rotating but naming a largely senior side, with the likes of Dani Ceballos, Nicolas Pepe and Alexandre Lacazette in reserve.
Liverpool: Kelleher; Williams, Gomez, Van den Berg, Milner; Lallana, Keita, Oxlade-Chamberlain; Elliott, Origi, Brewster
Substitutes: Adrian, Koumetio, Larouci Chirivella, Clarkson, Kane, Jones
Arsenal: Martinez; Bellerin, Holding, Mustafi, Kolasinac; Torreira, Willock, Maitland-Niles; Ozil, Saka, Martinelli
Substitutes: Macey, Sokratis, Tierney, Guendouzi, Ceballos, Pepe, Lacazette