If the Reds take all three points from this afternoon’s clash they will clinch a top-four finish, unless Leicester defeat Tottenham by a ridiculous scoreline.
There is even a chance of Liverpool finishing third, if Chelsea are unable to beat Aston Villa, with the last round of matches set to be a captivating watch.
Joining Henderson and Jota among the substitutes is midweek goalscorer Alex Oxlade-Chamberlain.
Christian Benteke is not part of the Palace side, with Roy Hodgson unable to name a full 20-man squad on his final game as a top-flight manager.
Substitutes: Adrian, N.Williams, Tsimikas, Henderson, Milner, Jones, Oxlade-Chamberlain, Shaqiri, Jota
Crystal Palace: Guaita; Ward, Cahill, Tomkins, Mitchell; Kouyate, Riedewald, McCarthy; Townsend, Zaha, Ayew
Substitutes: Butland, Kelly, Clyne, Van Aanholt, Schlupp, Rak-Sakyi, Mateta