Here are 10 things to know ahead of an intriguing match-up.
1. Bees make impressive start
The Bees have accumulated eight points from their opening five matches, starting off with a memorable win at home to Arsenal.
Last weekend’s 2-0 triumph at Wolves was also a standout result – they won 7-0 against Oldham on Tuesday, too – and current evidence suggests they will do enough to beat the drop.
It’s still early, days though.
2. Frank working wonders
The 47-year-old has worked wonders in west London since taking charge in 2018, taking them into the Championship playoffs in 2019/20 and going one better last season.
Not only that, but Frank has done it all in style, adopting a high-octane, ball-playing approach that draws comparison with Klopp’s.
This will be his biggest test in management to date – expect plenty of energy on the touchline on Saturday.
3. Ex-Red Canos in the ranks
Sergi Canos didn’t pull up any trees in a Liverpool shirt, with his sole appearance for the club coming against West Brom back in 2015/16.
The Spaniard didn’t allow his Anfield disappointment to affect his progress, though, and he has carved out an excellent career for himself at Brentford, these days playing as their right wing-back in a 3-5-2.
Still only 24, Canos has scored 33 goals and provided 31 assists in 214 games for the Bees, arguably making him one of their best players of the last decade.
He is sure to start this weekend and Liverpool must beware that dreaded curse of an ex-player coming back to haunt their former club.
4. Who’s missing for Liverpool?
The hope is that he will be back in the near future, but last season showed us that a short-term problem for him can suddenly become several months on the sidelines!
5. Trent’s back, so what’s the expected XI?
The positives are indeed that Liverpool can call upon the services of Trent again, after the 22-year-old missed the last two matches – a major boost for Klopp.
6. New stadium for Liverpool fans to enjoy
This is Liverpool’s first-ever meeting with Brentford in the Premier League – they haven’t faced each other in any competition since March 1989, when the Reds won 4-0 in an FA Cup quarter-final tie at Anfield.
Not only that, but those travelling to London on Saturday have a brand-new stadium to look forward to sampling on an away day.
The Brentford Community Stadium was unveiled last season and is a highly impressive arena, seating 17,250 people but providing an atmosphere that sounds like double that amount.
The Bees’ new home could be at its most raucous for the visit of Liverpool, so Klopp and his players need to be prepared.
7. Toney the danger man
Brentford are an expertly-drilled outfit who rely on a strong team ethic over individual brilliance, but Ivan Toney is one to watch this weekend.
The 25-year-old has been a fantastic signing for the Bees, netting 35 times in just 57 appearances, including 33 in the Championship last season.
Toney is also proving that he isn’t a striker who can’t cut it in the Premier League, already scoring twice in five matches in 2021/22.
8. Klopp hails “outstanding” Minamino
“Taki really is an outstanding talent. When he arrived, Liverpool were not really flying in the best stage of our life. No supporters in the stadium.
“The loan at Southampton really helped. Players need time, we just don’t give them that often enough.”
With midfield options sparse this weekend, could Klopp even consider using Minamino as a No.10 in a 4-2-3-1 system?
9. Attwell in charge in west London
Stuart Attwell has been confirmed as the referee on Saturday, with Paul Tierney on VAR duty.
Liverpool fans have reason to feel buoyed by Attwell’s appointment, considering the Reds have never lost a league game with him overseeing matters.
That’s a total of nine matches overall, the first of which was a 4-1 victory over Portsmouth in 2010 and the most recent the 3-0 win at Arsenal back in April.
Incidentally, this weekend will see history made in the Premier League, with Australian Jarred Gillett becoming the first foreign referee in the division.
10. Sky’s Saturday offering
Saturday’s match is live on Sky Sports Main Event and Sky Sports Premier League from 5pm (BST) and kickoff is at 5.30pm.
Alternatively, you can come and join us on our matchday live blog, with Henry Jackson keeping you entertained from 4.45pm.
Come on, you’d rather read his thoughts than listen to Gary Neville, right?