Here are 10 things to know ahead of a huge game.
1. Strong start from City… but not perfect
City were the bookies’ favourites to win the title going into the new season and that hasn’t changed after six games.
Sunday will tell us much more about both sides.
2. Grealish making his mark
Harry Kane may not have ended up joining City in a big-money move this summer, but Jack Grealish did.
The £100 million price tag was certainly an eye-opener, but the early signs suggest he will be a superb signing.
Grealish has two goals and assists apiece to his name already he has a level of confidence and swagger that means he won’t be daunted at Anfield, where his likely match up against James Milner will be a big focus.
3. Liverpool’s injuries & likely starting XI
Klopp will again be without the services of Trent Alexander-Arnold, with the right-back suffering from a groin issue.
4. Reds change of system?
Klopp has hinted that he could switch his system around, however, arguably suggesting that a 4-2-3-1 could come into effect:
“We could change system, there are quite a few things and we have time to train this week.
“There are a lot of things possible.”
That would allow Liverpool to field both Jota and Firmino, as has been the case against City in the past.
Should Klopp alter his formation, it would presumably mean Jones makes way, allowing Fabinho and Henderson to operate as a double pivot.
5. Predicting City’s team
Guardiola has a formidable squad at his disposal, being afforded the kind of riches that most managers can only dream of.
For that reason, it is never easy second-guessing how they will line up for any game.
The team should be similar to the one that beat Chelsea, though, with Ruben Dias and Aymeric Laporte at centre-back and Rodri being accompanied by Kevin De Bruyne and Bernardo Silva in the middle of the park.
Grealish, Gabriel Jesus and Phil Foden could make up the attack, with the latter in a false nine role and Jesus playing on the right-hand side to help out Joao Cancelo up against Mohamed Salah.
Predicted Man City XI: Ederson; Walker, Dias, Laporte, Cancelo; Rodri, De Bruyne, Bernardo; Jesus, Grealish, Foden.
6. Klopp hails Europe’s best
Speaking in his pre-match press conference, Klopp lauded City as the continent’s leading side at the moment, saying: “Man City for me are the best team in Europe at the moment.”
There could be an element of truth behind those comments, but Guardiola’s team still lost to PSG in midweek and Liverpool will fully believe they can win on Sunday.
Mind games? You decide…
7. City’s Anfield woes…with fans
City’s 4-1 win at Anfield last season came at a time when Liverpool were in disarray with injuries and there were no fans in stadiums.
Frankly, does it even count?
Aside from that victory, Anfield has been a horrible ground for City, with no wins coming there since way back in 2003.
8. Did You Know?
Milner has had a wonderful career, and while some may feel his spell at City was his most defining, the statistics suggest otherwise.
The 35-year-old has now made 254 appearances for Liverpool, whereas he only made 203 during his time at the Etihad.
When the Englishman joined the Reds, it was arguably seen as a career swansong, but instead, his achievements have gone on to surpass those at City.
What a player he has been.
9. Tierney under the spotlight
In what is a hugely high-profile game, the referee could end up playing a big part in the end result.
Michael Oliver is often tasked with taking charge of such occasions, but Paul Tierney has been given the honour this time around.
Liverpool were unbeaten in the four league matches that he refereed last season, with wins coming away to Chelsea and at home to Aston Villa, as well as draws against Man United (home) and Newcastle (away).
Tierney is yet to produce a red card in five outings this season, awarded one penalty overall, to Southampton away to Newcastle.
10. Sky’s Super Sunday offering
The match is live on Sky Sports Main Event and Sky Sports Football from 4pm (BST), with kickoff at 4.30pm.
Unfortunately, that does mean Martin Tyler will likely be commentating on the game, with Jamie Carragher and Gary Neville also getting in on the act.
Carragher’s interview with outgoing James Bond and big Liverpool fan Daniel Craig will air before the game.
Alternatively, Henry Jackson will be running our matchday live blog from 3.45pm, keeping you entertained and up-to-date, as long as his nerves allow him to.