“It makes a difference” in the eyes of Jurgen Klopp but not if you win both legs, and that’s what the Reds will be out to do, starting at Anfield this evening.
And the Liverpool faithful would not mind watching a carbon copy of the 4-0 win that was notched the last time the Gunners came to visit in November.
So can they do just that and set themselves up nicely for the second leg?
Check This Is Anfield for the latest team news ahead of the match.
You can also follow the game by downloading the This is Anfield app, including lineups, live coverage and all the reaction and analysis.
The match gets underway at 7.45pm (GMT) – or 2.45pm in New York, 11.45am in Los Angeles, 6.45am (Friday) in Sydney, 11.45pm in Dubai and 10.45pm in Nairobi.
Check our Rest of the World TV guide below for a list of TV broadcasters showing the match live.
Rest of the World
Supporters can find the Anfield showdown on the following channels worldwide:
K-SPORT 1, beIN SPORTS CONNECT, SuperSport MaXimo 1, DStv Now, Supersport Grandstand ROA, SuperSport Premier League ROA, ESPN2 Caribbean, ESPNPlay Caribbean, Star+, ESPN Argentina, Setanta Sports 2, beIN SPORTS 2, beIN Sports Connect, Kayo Sports, DAZN, Eleven Sports 1 Belgium, Play Sports, ESPN2 Andina, Arena Sport 2, ESPN Brasil, NOW NET e Claro, GUIGO, Astro SuperSport 2, Astro Go, Play Diema Xtra, Diema Sport 2, ESPN Chile, PPTV Sport China, ESPN Colombia, Sky Sport 7 beIN Sports, Sky HD, Arena Sport 3, Cytavision on the Go, Cytavision Sports 3, Nova Sport 2, DIGI GO, Eurosport Player Denmark, Viaplay Denmark, discovery+, 6’eren, Setanta Sports 2, Viaplay Estonia, V Sport Premium, V Sport 2 Finland, Elisa Viihde Viaplay, Free, beIN Sports 2, DAZN2, Nova Sports 1, 661 Cable Sports, 601 HD Sports Desk, Digi Sport 1, Stöð 2 Sport 2, Voot Select, JioTV, mola.tv, Mola TV App, Mola TV, Sky Sports Main Event, Sky Sports Football, Sky Ultra HD, SKY GO Extra, Sport 1, SPOTV ON, K-SPORT 1, Viaplay Latvia, Viaplay Lithuania, Blue To Go Video Everywhere, Ziggo Sport Voetbal, beIN Sports Connect New Zealand, SuperSport Premier League Nigeria, V4, Viaplay Norway, Eleven Sports 2 Poland, Eleven Sports 4 Poland, Sport TV Multiscreen, Sport TV2, Digi Sport 1 Romania, Digi Online, Sportbox.ru, Match! Football 2, matchtv.ru, Match! Football 1, Match TV, Arena Sport 1P, K-SPORT 1, 111 mio Sports 1, Nova Sport 2, Arena Sport 1 Slovenia, SuperSport Premier League, Supersport Grandstand, DStv App, Movistar+, Viaplay Sweden, AIS PLAY, PPTV HD 36, beIN Sports 2 Turkey, beIN CONNECT Turkey, Turkmenistan Sport, ESPN+, ON Sports Premium, VTVcab ON
You can follow all the action tonight and throughout the 2021/22 season with us by downloading the This is Anfield app for iPhone and Android for free.