Victory is essential for Rafa Benitez’s men to keep up the pressure on league leaders Manchester United, who extended their lead at the top to six points with a win at Middlesbrough yesterday.
Gerrard starts for the first time since April 8th, but striker Fernando Torres is sidelined through a reoccurrence of an hamstring injury.
Daniel Agger, who signed a new contract with the Reds this weekend, comes in for Martin Skrtel at centre-back.
Dirk Kuyt looks set to spearhead the Liverpool attack with Albert Riera and Yossi Benayoun manning the wings.
Liverpool: Reina, Arbeloa, Aurelio, Carragher, Agger, Mascherano, Alonso, Kuyt, Benayoun, Gerrard, Riera. Subs: Cavalieri, Skrtel, Ngog, Dossena, Babel, Lucas, El Zhar.
Newcastle meanwhile have left former Red Michael Owen on the bench.
Kick-off at Anfield is 1.30pm and you can follow it live with other fans in our forums or chat room. The game is live on Setanta Sports in the UK.