The Reds are looking for their first win in Group B, having drawn their opening three games 1-1.
Jordon Ibe replaces Adam Lallana, and Joe Allen comes in for Lucas in midfield.
Tonight’s match is live on BT Sport Showcase in the UK – Freeview channel 59.
Liverpool: Mignolet, Clyne, Sakho, Lovren, Moreno, Can, Allen, Milner, Ibe, Firmino, Benteke.
Subs: Bogdan, Coutinho, Lallana, Lucas, Origi, Brannagan, Skrtel.
Rubin Kazan: Ryzhikov, Kverkvelia, Cotugno, Kambolov, Nabiullin, Carlos Eduardo, Kislyak, Gokdeniz Karadeniz, Georgiov, Devic, Kanunnikov.
Subs: Haghighi, Lemos, Ustinov, Akhmetov, Bilyaletdinov, Ozdoev, Dyadyun.
Our usual match coverage will begin shortly.