The starting lineup for the initial 0-0 draw at Anfield was the Reds’ youngest in history, with Klopp utilising his academy ranks to form an impressive unit.
With injuries and international duty hampering his senior ranks in January, Klopp has taken a similar approach for the trip to Home Park, with a few more familiar names.
Loris Karius resumes his duties between the sticks, and will be hoping to continue his fine run of form in cup competitions after a difficult start to life on Merseyside.
With Sadio Mane at the Africa Cup of Nations with Senegal, and Adam Lallana, Georginio Wijnaldum and Roberto Firmino rested, Klopp has turned to Ben Woodburn, Daniel Sturridge and Divock Origi as his forward trio.
Plymouth Argyle: McCormick; Threlkeld, Songo’o, Bradley, Purrington; Fox, Carey, Donaldson; Jervis, Slew, Garita
Substitutes: Dorel, Sawyer, Bulvitis, Rooney, Tanner, Fletcher, Rose
Liverpool: Karius; Alexander-Arnold, Gomez, Lucas, Moreno; Stewart, Coutinho, Ejaria; Origi, Woodburn, Sturridge
Substitutes: Mignolet, Klavan, Randall, Williams, Alves, Ojo, Wilson