The Reds take on their bitter rivals in their second game of October, looking to respond to a disappointing 1-1 draw to Newcastle United before the international break.
Since their 4-0 victory at home to Arsenal at the end of August, Klopp’s side have endured a miserable run of form, winning just once in seven games.
With Jose Mourinho’s United arriving on Merseyside joint-top of the Premier League, yet to lose in the English top flight, the challenge is clear.
And Klopp has been forced to deal with the absence of Sadio Mane, with the winger sidelined for the next six weeks with a hamstring injury picked up on Senegal duty.
The German is still able to name a strong side, however, with the summer transfer window at least providing more fitting replacements for the No. 19.
United have seemingly opted for a back five, with Matteo Darmian expected to play at centre-back, as Mourinho looks to counter the threat of Coutinho.
Liverpool: Mignolet; Gomez, Matip, Lovren, Moreno; Henderson, Can, Wijnaldum; Salah, Coutinho, Firmino
Substitutes: Karius, Klavan, Alexander-Arnold, Milner, Oxlade-Chamberlain, Solanke, Sturridge
Man United: De Gea; Valencia, Darmian, Smalling, Jones, Young; Matic, Herrara; Mkhitaryan, Martial, Lukaku
Substitutes: Romero, Lindelof, Tuanzebe, Blind, Mata, Lingard, Rashford