The Reds take to the London Stadium to face off with a Hammers side that has won just twice in their first 10 league games this season.
Buoyed by back-to-back victories over Huddersfield Town and Maribor, and a 4-0 win away to West Ham in May, Liverpool can hope for another positive evening in Stratford.
And with the November international break looming, Klopp has named a strong starting lineup, as he looks to keep up the pressure on the rest of the top six.
West Ham: Hart; Kouyate, Reid, Ogbonna, Fernandes, Cresswell; Ayew, Obiang, Noble, Lanzini; Hernandez
Substitutes: Adrian, Rice, Masuaku, Haksabanovic, Arnautovic, Carroll, Sakho
Liverpool: Mignolet; Gomez, Matip, Klavan, Moreno; Can, Wijnaldum, Oxlade-Chamberlain; Salah, Mane, Firmino
Substitutes: Karius, Lovren, Alexander-Arnold, Milner, Grujic, Sturridge, Solanke