The 25-year-old made his way back from Senegal duty midway through the November break as a precaution following his hamstring injury last month.
This cast doubt over Mane’s fitness as Liverpool prepare to take on the Saints in the Premier League, and he did not take part in training at Melwood on Wednesday.
But with Jurgen Klopp himself returning to take Thursday’s session after a short illness, the German was given a major lift as Mane was passed fit.
This means Klopp’s only injury concern ahead of Saturday is Nathaniel Clyne, with the right-back sidelined until February with a back problem.
Clyne underwent surgery on Monday, and is expected to make his comeback during next year’s run-in.
Mane’s availability raises an interesting, but positive, quandary for Klopp as he plots for only his second victory in eight games against Southampton.
And this is overlooking to possibility of leaving out an in-form Alex Oxlade-Chamberlain, whose performance at the London Stadium does not warrant dropping back onto the bench.
Klopp is now blessed with a plethora of quality in both midfield and attack, and he is likely to be able to name one of the strongest substitutes’ benches in Liverpool’s recent history.
That this leaves out the likes of Grujic and Ben Woodburn, too, further highlights this.
But given Liverpool play 13 times in his 45 days from Saturday, the 50-year-old will need to rotate, and call upon his strong squad ranks, to survive.