Trips to Selhurst Park are never the most comfortable of affairs, so Jurgen Klopp‘s side will need to be at their best in south London.
Here’s a look at the other nine matches taking place on the second weekend of Premier League action.
Cardiff vs. Newcastle – Saturday, 12.30pm – Sky Sports
After both suffering defeats last weekend, two relegation candidates meet at St James’ Park.
For Cardiff City it’s a first home game back in the Premier League, while off-field matters continue to hamper Rafa Benitez and his Newcastle United players.
It could feel like a six-pointer come the business end of the season.
Prediction: Cardiff 1-1 Newcastle
Everton vs. Southampton – Saturday, 3pm
Go and do the business and silence the blue half of Merseyside, Danny!
Leicester City vs. Wolves – Saturday, 3pm
The Foxes may just have the edge, though, having made a decent account of themselves at Man United.
Tottenham vs. Fulham – Saturday, 3pm
It’s an all-London clash at Wembley, as Tottenham host Fulham in what will continue to be Spurs’ temporary home for the time being.
Mauricio Pochettino’s men proved that no summer transfer business was no big issue, seeing off Newcastle last Saturday, but Fulham’s 2-0 loss at home to Crystal Palace was a surprise.
The Premier League newcomers won’t trouble Spurs too much here.
Prediction: Tottenham 2-0 Fulham
West Ham vs. Bournemouth – Saturday, 3pm
This is their chance to bounce back in style, however, as they face a Bournemouth team who continue to over-perform in the top flight.
The money will be on the Hammers, but it’s easy to envisage a frustrating day at the office for them.
Chelsea vs. Arsenal – Saturday, 5.30pm – BT Sport
The Gunners’ record at Stamford Bridge is pitiful—don’t expect that to change on Saturday evening.
Burnley vs. Watford
Sean Dyche and his players host Watford on Sunday lunchtime, in what on paper does not look like a classic for the ages.
Man City vs. Huddersfield – Sunday, 1.30pm – Sky Sports
City were impressive without ever being at their best against Arsenal and Sunday’s trip to the Etihad looks a daunting one for Huddersfield.
Kevin De Bruyne’s injury is a major blow but Pep Guardiola has so much attacking quality at his disposal that they will not struggle to break the Terriers down.
David Wagner may just be out to avoid a cricket score.
Prediction: Man City 4-0 Huddersfield
Brighton vs. Man United – Sunday, 4pm – Sky Sports
This is the latest opportunity to gauge Jose Mourinho’s mental state, as United head to Brighton for Sky Sports’ Sunday afternoon offering.
These are the matches Mourinho is a master at nicking three points in and a win would further ease the feel of doom and gloom at Old Trafford.
A Brighton win, or at least a draw, would be greatly appreciated. But don’t bank on it.