The Reds took four wins from a possible four before the September international break, with only two other sides also boasting a perfect record heading into the weekend.
One of those, Watford, shocked Spurs last time out, which could either provoke a response from Liverpool’s hosts or see them return to action lacking momentum.
Klopp will be hoping for the latter, as his side head back to the scene of last season’s most draining defeat, with their 4-1 loss to Spurs almost a year ago serving as a jolt to the system.
The manager has kept faith with the majority of the side that earned a hard-fought 2-1 win at Leicester City before the break, in a bid to maintain pole position.
Alisson starts in goal, having been left out of Brazil’s 5-0 friendly win over El Salvador on Wednesday morning, though he only reported back for training on Thursday.
Alexander-Arnold makes his 50th appearance for the first team, against the side he made his debut against back in October 2016.
Tottenham: Vorm; Trippier, Alderweireld, Vertonghen, Rose; Dier, Dembele, Winks; Eriksen, Lucas, Kane
Substitutes: Gazzaniga, Sanchez, Aurier, Davies, Wanyama, Lamela, Son
Liverpool: Alisson; Alexander-Arnold, Gomez, Van Dijk, Robertson; Wijnaldum, Milner, Keita; Salah, Mane, Firmino
Substitutes: Mignolet, Moreno, Matip, Fabinho, Henderson, Shaqiri, Sturridge