Exacting revenge on the Blues and preserving the perfect Premier League start is Liverpool’s aim after losing for the first time this season in midweek.
Klopp rotated his team for the League Cup loss, preserving first choice picks for this more important league meeting which marks the first of three huge games over the next eight days.
It’s safe to assume those key men rested will be recalled in attempt to return to winning ways and extend the early gap at the top of the table.
However, a big concern presents with van Dijk, who is a doubt with a rib injury sustained against Southampton last weekend.
So here is how Liverpool’s starting XI could look with and without the world-class centre-back.
The Reds to be recalled
It’s no secret that Klopp will recall his big guns and specifically those rested for Saturday’s heavyweight clash.
The boss will desperately hope – along with the entire fan base – Van Dijk is included.
After being rested for the cup tie, Gini Wijnaldum is certain to start in midfield.
Fighting for starts
Few of those given chances to shine in the League Cup seized their moment but a number of Reds will be hoping for the nod from Klopp.
Fabinho will hope for the chance to build on his full debut but will likely feature among the subs.
Xherdan Shaqiri will be hoping successive eye-catching displays earn him a third straight start.
It’s likely the two attackers will also drop back to the bench however.
The potential lineups
All connected with the Reds will pray Van Dijk recovers, and if the centre-back does then the team will be back to full strength in all areas.
The selection can then be pieced together with it safe to assume the other seven rested Reds will all return.
Alisson, Alexander-Arnold, Gomez and Robertson will join van Dijk to reunite the first choice defence.
Salah and Firmino will link up with Mane to restore full fire power to the front line and in midfield the refreshed Wijnaldum will start.
It’s just a question of who from Henderson, Milner and Keita join the Dutchman, and it seems simple when reading between the lines of Klopp’s changes in the League Cup loss.
Neither Henderson nor Milner played all of the game whereas Keita did.
And that the skipper replaced his understudy on the hour-mark spoke volumes, with this clearly a substitution designed to ensure both are fresh for Saturday.
So a Henderson-Wijnaldum-Milner midfield looks nailed on; an understandable choice given previous success the energetic trio has had in disrupting big opponents, most recently seen against PSG.
Everything rests on Van Dijk’s fitness but there remains a realistic chance that the £75million man is unavailable.
Matip and Lovren present the go-to options and both will be hoping for the chance to prove their capabilities as part of the new-look defensive unit
There are reasons for starting both but Lovren, historically the first choice pick, could get the gig now he is game ready having completed his first 90 minutes of the season in midweek.
That potentially enforced alteration to the changes planned would mean this Liverpool side take on Chelsea:
Wednesday’s cup loss was disappointing but the Reds must move on swiftly and bounce back to winning ways to keep momentum building for the more important title surge.