Stadio San Paolo provides the setting for the Reds’ first away game of the European campaign, as Klopp’s side look to build on their 3-2 victory over PSG at Anfield.
Liverpool have not been in Naples since their 0-0 draw under Roy Hodgson back in 2010, when the likes of Paul Konchesky, Christian Poulsen and David N’Gog struggled in the Europa League.
This time out, they are a significantly improved side, with Klopp showcasing the strength of his squad as he makes one change from Saturday’s 1-1 draw at Chelsea.
Alisson keeps his place in goal a day after his 26th birthday, returning to the field in Italy having left Roma in July.
Napoli: Ospina; Abiol, Maksimovic, Koulibaly, Rui; Allan, Fabian, Hamsik; Callejon, Insigne, Milik
Substitutes: Karnezis, Hysaj, Diawara, Rog, Zielinski, Mertens, Verdi
Liverpool: Alisson; Alexander-Arnold, Gomez, Van Dijk, Robertson; Wijnaldum, Milner, Keita; Salah, Mane, Firmino
Substitutes: Mignolet, Lovren, Moreno, Fabinho, Henderson, Shaqiri, Sturridge