Three points over City would push the Reds a long way towards the title, and the pressure is on the hosts after failing to win either of their meetings last season.
A loss and a draw undermined a record-breaking campaign for Klopp’s side, finishing just a point behind City, but so far this season Liverpool are in a much stronger position.
Six points clear at the top, the Reds can extend this to nine with victory on home soil, and Klopp has named his tried-and-trusted lineup in order to do so.
In midfield, Fabinho makes his first league start for Liverpool against City, having been limited to just 33 minutes in the two meetings in 2018/19.
Meanwhile, Ederson misses out for City as Claudio Bravo starts in goal and Scott Carson takes his place on the bench.
Substitutes: Adrian, Gomez, Milner, Lallana, Keita, Oxlade-Chamberlain, Origi
Man City: Bravo; Walker, Stones, Fernandinho, Angelino; Rodrigo, Gundogan, De Bruyne; Bernardo, Sterling, Aguero
Substitutes: Carson, Otamendi, Cancelo, Silva, Foden, Mahrez, Jesus