The Reds enjoyed a drama-free victory on Saturday, easing to a 3-0 win away to an ineffective Bournemouth side.
Klopp’s men are two matches into a relentless December that could see them play nine times across four different competitions.
Next up is Tuesday’s trip to Salzburg, with Liverpool knowing that avoiding defeat will see them reach the Champions League knockout stage.
Rotation has been the order of the day of late and that should be no different at the Red Bull Arena.
Liverpool’s Starting XI vs. Salzburg
There are elements of Liverpool’s team that picks itself on Tuesday, given their injury problems at the back.
Gomez was used at right-back against Bournemouth, but his shift to a central berth will coincide with Alexander-Arnold returning.
The same applies to Wijnaldum, though, and with Milner starting the last two matches, the Dutchman will surely replace him.
Alisson; Trent, Gomez, Van Dijk, Robertson; Henderson, Wijnaldum, Oxlade-Chamberlain; Salah, Mane, Firmino
Given Klopp’s recent rotation, this team is far from a given.
The defence should be nailed-on, but the manager could easily go with a lineup as much-changed as the Everton one last week.
Wijnaldum could take up the deep-lying role, with Henderson given the night off, while Keita and Oxlade-Chamberlain make up an exciting-looking attacking midfield duo.
The returning Lallana is also an option, though.
Alisson; Trent, Gomez, Van Dijk, Robertson; Wijnaldum, Keita, Oxlade-Chamberlain; Shaqiri, Mane, Origi
Second-guessing Klopp is often difficult, but at this time of year that becomes even more prevalent.
He has made it clear that he will be making several changes each game, however, so we will almost certainly see something different to Bournemouth.
It will be a tough night for Liverpool, with the match acting as a cup final for Salzburg – arguably the biggest night in their history.
Should the Reds lose and Napoli win at home to Genk, their Champions League defence will end in rather embarrassingly early fashion.