The Reds have already sealed victories over Ajax and Midtjylland in Group D, and would record a historic treble if they are able to vanquish their first-time opponents this evening.
Never before have Liverpool won their first three group games in the Champions League, but come up against an unfamiliar foe at the Stadio di Bergamo, having never previously taken on Atalanta.
The manager is likely to use as five available substitutions again, as he manages the fitness of his squad leading up to arguably the biggest game of the season yet this weekend.
Atalanta: Sportiello; Toloi, Palomino, Djimsiti; Hateboer, Pasalic, Freuler, Mojica; Gomez; Zapata, Muriel
Substitutes: Gollini, Rossi, Depaoli, Ilicic, Lammers, Malinovsky, Miranchuk, Pessina, Romero, Ruggeri, Scalvini, Traore
Liverpool: Alisson; Alexander-Arnold, R.Williams, Gomez, Robertson; Henderson, Wijnaldum, Jones; Salah, Mane, Jota
Substitutes: Adrian, Kelleher, Matip, Tsimikas, N.Williams, Milner, Keita, Cain, Shaqiri, Minamino, Origi, Firmino