The Reds are currently top of Group D after overcoming both Ajax and Midtjylland, but face arguably their biggest test yet as they take on second-placed Atalanta.
A visit to the Stadio di Bergamo will be Liverpool’s first, and Klopp was full of praise for Atalanta in his pre-match press conference, with the Serie A side scoring 98 league goals last season.
Fortunately, the manager is boosted by an improvement in his options in defence for this tie, with Joel Matip among the players available in Lombardy.
Here’s how Liverpool could line up on Tuesday night.
Injuries and ineligibles
And while the Reds are able to name an expanded squad in the Champions League, and Klopp is permitted to make five changes per game, the manager is restricted by registration.
Neither Koumetio nor Nat Phillips were named in Liverpool’s squad for the group stage and are therefore ineligible, which leaves it likely that either Matip or Rhys Williams will partner Joe Gomez at the back.
A 19-man outfield group trained at Melwood on Monday afternoon, with James Milner working separately, but there is no indication at this stage that the vice-captain is ruled out.
Liverpool’s XI vs. Atalanta
Though the word ‘crisis’ has been frequently, and rightly, used to describe Liverpool’s issues at centre-back of late, ahead of this game there are more absences in midfield.
With there question marks over Milner’s involvement, and Naby Keita unlikely to be thrown straight back into the starting side, there are few genuine options for Klopp to select from.
At the back, Alisson is an obvious pick between the sticks and, if Matip is, like Keita, not deemed fit enough, Williams should partner Gomez at centre-back with Trent Alexander-Arnold and Andy Robertson.
Alisson; Alexander-Arnold, R.Williams, Gomez, Robertson; Henderson, Milner, Wijnaldum; Salah, Mane, Firmino
However, there is scope for rotation in Lombardy, which could see Klopp deploy a 4-2-3-1 formation and shuffle his pack in attack.
With Matip back in the mix, the No. 32 could make his first-ever start alongside Gomez, with Alisson, Alexander-Arnold and Robertson all effectively guaranteed to feature in defence.
Doubt over Milner’s involvement could see Klopp turn to Henderson and Wijnaldum as a double pivot, and hand some of his in-form squad players a chance in the forward line.
Alisson; Alexander-Arnold, Matip, Gomez, Robertson; Henderson, Wijnaldum; Salah, Shaqiri, Jota; Minamino
Atalanta are a dangerous side, who focus a lot of their attacks through the central areas, and as such it could be more sensible to set up with a three-man midfield.
But with uncertainty over the fitness of Keita and Milner and the form of Jones, perhaps Klopp will mix things up and push for the win with a new-look attack in the Champions League.