The Reds beat the Foxes in the League Cup in stunning fashion last week, prevailing on penalties after a frenetic 3-3 draw at Anfield.
Here are 10 things to know ahead of the game.
1. Leicester continue their struggles
Former Liverpool manager Rodgers is having a tough time juggling injuries, European football and defensive woes, with their 6-3 loss at Man City on Boxing Day summing up their issues.
The Foxes are 10th in the table and already 13 points adrift of fourth-placed Arsenal, albeit with two games in hand.
Liverpool must be ruthless at the King Power, making the most of both their superiority and the fact they have had a longer rest since their last game.
2. Maddison a man in form
A number of Leicester players have failed to find top gear in 2021/22, but one of their bright sparks has been James Maddison.
After a noticeable dropoff last year, the Englishman has been back to his best of late, producing a superb performance against City despite the end result.
Maddison has scored six goals and registered five assists in his last eight appearances, including a stunner in front of the Kop last week.
He is the man to be wary of on Tuesday evening.
3. Who’s available for Leicester?
Leicester have been hit hard by Covid in recent weeks, with a host of important players ruled out of action at different times.
Those problems are easing, however, and the likes of Wilfred Ndidi and Jamie Vardy could start after being left out of the starting lineup away to City.
The injury list is brutal, though, with Ricardo Pereira out for a lengthy period after being on the receiving end of a late tackle by Tyler Morton in the League Cup clash.
James Justin, Caglar Soyuncu, Wesley Fofana, Jonny Evans, Ryan Bertrand, Harvey Barnes and Patson Daka are all still out, too.
Possible Leicester XI: Schmeichel; Daley-Campbell, Amartey, Vestergaard, Castagne; Ndidi, Tielemans, Soumare; Perez, Iheanacho, Vardy
4. Who’s out for Liverpool?
Divock Origi is also likely to miss out, as the Belgian continues to recover from a knee problem.
Klopp has confirmed that “one young player and two staff [members] are now isolating”, though, as the virus continues to cause issues.
5. Predicted Liverpool starting lineup
Legs should be well-rested after the Boxing Day clash with Leeds was postponed, so Liverpool will be as close to full strength as possible.
6. Klopp calls for five subs
“Yes, that’s probably true – whatever that means exactly, because it’s still Premier League and they can still cause us problems.
“But if you talk about the quality, without playing, just the transfer market and all these kinds of things, then that’s the case.
“The problem is, obviously, this intensity. For a top-class footballer in England, it’s definitely on the edge.”
As always, there’s no selfishness from the Liverpool manager – he genuinely cares about the welfare of all players.
7. Hit-and-miss record at Leicester
Liverpool haven’t had things their own way at the King Power in recent years, with results often difficult to predict.
A 3-1 defeat there back in February came during a shocking period for Klopp’s men – a time when key defenders were injured, stadiums were empty and nothing was going their way.
The Reds won 4-0 at the Foxes in the title-winning season, however, in what may always go down as the defining performance of that campaign.
It was a near-perfect display in what looked like a potential banana skin, showing that nobody could touch Liverpool that year.
In total, Liverpool have won three of their last five at the King Power, losing twice.
8. Did you know?
Tsimikas is set to start on Tuesday and one eye-catching statistic concerning the Greek bodes well going into the game.
The left-back has started four Premier League matches this season – not only have Liverpool won every one, but they also haven’t conceded a single goal.
9. Oliver in charge
Michael Oliver will take charge of Tuesday’s meeting, with the 36-year-old generally considered the best in England.
Meanwhile, Stuart Attwell is on VAR duty at the King Power.
10. A rare Amazon Prime offering
Tuesday’s action will be live on Amazon Prime, with kickoff at 8pm (GMT).
That hopefully means those not fortunate enough to be at the game will be treated to the commentating brilliance of Ally McCoist.
Alternately, our TIA matchday live blog is available from 7.15pm, with Henry Jackson keeping you company throughout the evening.