A positive lateral flow test will see Klopp miss the trip to Stamford Bridge as a precautionary measure, with the 54-year-old believed to have a case of COVID-19.
He is, therefore, also likely to miss the League Cup quarter-final first leg against Arsenal on Thursday evening, which would be the fifth first-team game Liverpool have been without Klopp throughout his six-year-plus reign so far.
But Klopp has already been required to miss a game on medical grounds, too, that coming just four months after taking over at Anfield.
He had already spoken to journalists as part of his pre-match press conference when he fell ill, with an emergency appendix removal needed on December 6, 2016.
It was certainly an eventful afternoon, with a 2-2 draw played as masses of fans walked out in the 77th minute, in protest of Fenway Sports Group’s plan for a £1,000 season ticket and Main Stand seats rising from £59 to £77.
The Welshman, along with Dejan Lovren, was forced off before half-time, though, with the opening 45 minutes seeing wasteful finishing from James Milner and Alberto Moreno that undermined Liverpool’s dominance.
But the departure of thousands of supporters seemed to suck the momentum out of the game, and the visitors capitalised with two late goals.
Adam Johnson struck first, with Simon Mignolet failing at his near post from a creeping free-kick, before Mamadou Sakho allowed Jermain Defoe to turn and fire home the equaliser in the 89th minute.
Buvac was a composed figure on the touchline, but the atmosphere clearly impacted Liverpool, particularly without their leader.
Speaking two days later, Klopp declared himself “back in the race,” and assessing a poor run of 11 Premier League games in which his side had won only three times, losing five and drawing three, said: “We have to carry on.”
The circumstances of Klopp’s absence from the trip to Chelsea are considerably different, and it is likely he will relay information to Lijnders from his isolation at home this time.
Either way, Liverpool will be hoping for a more positive result than that 2-2 draw with Sunderland almost six years ago.
Liverpool 2-2 Sunderland
Premier League, Anfield
February 6, 2016
Goals: Firmino 59′ Lallana 70′; Johnson 82′, Defoe 89′
Liverpool: Mignolet; Clyne, Lovren (Toure 12′), Sakho, Moreno; Henderson (Lucas 86′), Can; Milner, Lallana, Allen (Ibe 45+2′); Firmino
Subs not used: Ward, Flanagan, Benteke, Sturridge