Rickie Lambert makes his full debut for the club too, having only featured as a substitute thus far, Lambert captains the side.
Manager Brendan Rodgers has named a strong XI, with Simon Mignolet in goal and Raheem Sterling starting in attack.
Jose Enrique makes his first start for Liverpool since last October.
Former Liverpool defender Daniel Ayala is in the Middlesbrough line-up.
Kick off at Anfield is 7.45pm.
Liverpool: Mignolet, Manquillo, Toure, Sakho, Enrique, Lucas, Rossiter, Lallana, Sterling, Markovic, Lambert.
Subs: Jones, Sktrel, Moreno, Williams, Suso, Borini, Balotelli.
Middlesbrough: Blackman; Fredericks, Ayala, Omeruo, Friend; Adomah, Leadbitter, Clayton, Reach; Tomlin, Kike.
Subs: Dimi, Husband, Gibson, Nsue, Vossen, Bamford, Wildschut.