Joe Allen also comes back into the midfield alongside Jordan Henderson and Steven Gerrard.
Raheem Sterling and Coutinho support Mario Balotelli in attack.
Glen Johnson is given the nod at right back ahead of Javier Manquillo.
The points were shared in this match last season in a 2-2 draw.
Newcastle v Liverpool kicks off at 12.45pm (UK).
Liverpool: Mignolet, Johnson, Lovren, Skrtel, Moreno, Gerrard, Allen, Henderson, Coutinho, Sterling, Balotelli.
Subs: Jones, Toure, Manquillo, Lallana, Can, Lambert, Borini.
Newcastle: Krul, Danmaat, Taylor, Coloccini, Dummett, Abeid, Colback, Obertan, Sissoko, Ameobi, Cisse.
Subs: Elliot, Haidara, R.Taylor, Aarons, Cabella, Gouffran, Perez.