Sturridge is understood to have picked up a knee injury in training this week.
It’s a very inexperienced bench, with youngster Jerome Sinclair Connor Randall and Joao Carlos Teixeira named in the squad.
No Liverpool manager since Graeme Souness in 1991 has won their opening league game at Liverpool. Rafa Benitez’s first league game was also away to Tottenham in 2004, which ended in a 1-1 draw.
* = loaned out
Liverpool: Mignolet, Clyne, Skrtel, Sakho, Moreno, Can, Lucas, Milner, Coutinho, Lallana, Origi.
Subs: Bogdan, Toure, Allen, Ibe, Sinclair, Teixeira, Randall.
Tottenham: Lloris, Walker, Alderweireld, Vertonghen, Rose; Alli, Dembele; Chadli, Eriksen, Lamela; Kane.
Subs: Vorm, Davies, Trippier, Wimmer, Clinton, Townsend, Winks.