This includes a starting role for Jordan Henderson, returning from a heel injury to captain his side.
Replacing the shaky Adam Bogdan in goal is Simon Mignolet, with the Belgian reverting to his role as Klopp’s first choice, having provisionally agreed a new five-and-a-half year contract.
Sakho was struggling with a knee injury in the buildup to this Anfield encounter but was deemed fit to start, having been determined to feature.
New signing Steven Caulker has to make do with a place on Klopp’s substitutes’ bench, but provides ample cover at centre-back, with question marks over the fitness of both Toure and Sakho.
Caulker will make himself comfortable alongside returning loanee Danny Ward, Brad Smith, Lucas Leiva, Joe Allen, Joao Carlos Teixeira and Christian Benteke.
Taking on a strong Arsenal side, Klopp will be hoping his reinvigorated Reds can claim another big win over their top-four rivals, having already vanquished Chelsea, Manchester City and Leicester City in his three months on Merseyside.
Liverpool: Mignolet; Clyne, Toure, Sakho, Moreno; Can, Henderson, Milner; Lallana, Firmino, Ibe
Substitutes: Ward, Caulker, Smith, Lucas, Allen, Teixeira, Benteke
Arsenal: Cech; Bellerin, Koscielny, Mertesacker, Monreal; Flamini, Ramsey; Campbell, Ozil, Walcott; Giroud
Substitutes: Macey, Gibbs, Gabriel, Chambers, Arteta, Oxlade-Chamberlain, Iwobi