This includes a starting role for Jordan Henderson, returning from a heel injury to captain his side.
Replacing the shaky Adam Bogdan in goal is Simon Mignolet, with the Belgian reverting to his role as Klopp’s first choice, having provisionally agreed a new five-and-a-half year contract.
Sakho was struggling with a knee injury in the buildup to this Anfield encounter but was deemed fit to start, having been determined to feature.
New signing Steven Caulker has to make do with a place on Klopp’s substitutes’ bench, but provides ample cover at centre-back, with question marks over the fitness of both Toure and Sakho.
Taking on a strong Arsenal side, Klopp will be hoping his reinvigorated Reds can claim another big win over their top-four rivals, having already vanquished Chelsea, Manchester City and Leicester City in his three months on Merseyside.
Liverpool: Mignolet; Clyne, Toure, Sakho, Moreno; Can, Henderson, Milner; Lallana, Firmino, Ibe
Substitutes: Ward, Caulker, Smith, Lucas, Allen, Teixeira, Benteke
Arsenal: Cech; Bellerin, Koscielny, Mertesacker, Monreal; Flamini, Ramsey; Campbell, Ozil, Walcott; Giroud
Substitutes: Macey, Gibbs, Gabriel, Chambers, Arteta, Oxlade-Chamberlain, Iwobi