Nathaniel Clyne drops out after playing the full game against City three days after the 120 minutes at Wembley, that means Jon Flanagan continues at right-back, with Alberto Moreno back in at left-back.
Sakho replaces Kolo Toure at the back.
Palace, who haven’t won in their last 11 league games, replace regular keeper Wayne Hennessey with Alex McCarthy. Yannick Bolasie starts.
Kick off is 1.30pm GMT, our live blog coverage starts at 1pm.
Liverpool: Mignolet, Flanagan, Lovren, Sakho, Moreno, Can, Henderson, Milner, Firmino, Lallana, Origi.
Subs: Ward, Clyne, Toure, Allen, Coutinho, Sturridge, Benteke.
Crystal Palace: McCarthy; Ward, Dann, Delaney, Souare; Zaha, Jedinak, Cabaye, Ledley, Bolasie; Adebayor.
Subs: Speroni, Kelly, Lee, Mutch, Sako, Chamakh, Gayle.