The Brazilian spent the first weeks of the summer on holiday following his exploits with Brazil at the Copa America Centenario, but returned to Merseyside on Monday.
After sitting out the Reds’ 5-0 win over Fleetwood Town on Wednesday night, Coutinho is set to start against Gary Caldwell’s Latics.
Twenty-year-old academy midfielder Cameron Brannagan is joined by Kevin Stewart in midfield, in what is likely to be a 4-2-3-1 formation.
Under-21s goalkeeper Shamal George replaces Adam Bogdan on the bench, with Andre Wisdom, Tiago Ilori, Ryan Kent, Lazar Markovic and Ben Woodburn also poised to feature at some point at the DW Stadium.
Lovren captains the Reds against a Wigan side missing the majority of their regular starters, following yesterday’s friendly defeat to Manchester United.
Liverpool: Karius; Randall, Lovren, Matip, Flanagan; Brannagan, Stewart; Mane, Ejaria, Coutinho; Firmino
Substitutes: George, Wisdom, Ilori, Lucas, Alexander-Arnold, Kent, Markovic, Woodburn, Ings