Can returned to training at the end of last week, but sat out of Sunday morning’s 2-0 win over AC Milan as he continued to build his fitness.
But as the Reds round off their tour of the US, the German is included in an exciting attacking side.
Veteran goalkeeper Alex Manninger has been given his debut for the Reds, after signing on a free transfer this summer, and the Austrian will operate behind a solid back four.
Joining Can in midfield is Georginio Wijnaldum, in what is likely to be a 4-2-3-1 formation.
Klopp’s defensive reserves include Shamal George, Simon Mignolet, Andre Wisdom, Connor Randall, Trent Alexander-Arnold and Alberto Moreno, while in midfield he could call upon Jordan Henderson, Cameron Brannagan and Kevin Stewart as replacements for Can and Wijnaldum.
Liverpool XI vs. AS Roma: Manninger; Clyne, Lovren, Klavan, Milner; Can, Wijnaldum; Mane, Firmino, Ojo; Sturridge
Substitutes: Mignolet, George, Wisdom, Randall, Alexander-Arnold, Moreno, Stewart, Brannagan, Henderson, Lallana, Coutinho, Markovic, Benteke, Ings